It is actually much easier to bus from the United States to Central America than most imagine. It is a distance of about 1000 miles from the US border at Brownsville to the Guatemalan/Mexican border. The trip can be done in one full day (strongly not recommended), instead the wise traveller would take his time and enjoy the many interesting sites along the way such as Real de Catorce, Veracruz, Xalapa, San Cristobal de las Casas, Palenque etc. Bus fare from Brownsville to the Guate border runs about $130 USD currently (Jan 08).
From the Guatemalan Border, one can take a bus like the Tica Bus to get to Panama or any of the CA-4 countries for around 130 USD or less.
There are no roads leading to Colombia from Central America.
The Most Frequently Asked Travel Questions about Central America
Where To Stay & Best Hotels in Central America - updated Apr 2024
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Central America Travel Guide from Wikitravel. Many thanks to all Wikitravel contributors. Text is available under Creative Commons Attribution-ShareAlike 3.0, images are available under various licenses, see each image for details.